Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). Hydroxychloroquine maculopathy Plaquenil similar Long term effects of hydroxychloroquine Chloroquine resistant area These points may be only mildly depressed. Further, HCQ retinopathy leads to a partial bull's eye scotoma that may resemble an arcuate defect although it is more central than that commonly seen from glaucomatous damage Fig. 1. Late toxicity may present as complete bull's eye scotoma, with a complete ring defect, relatively sparing the fovea. More in Eye Health. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Your eye care provider can examine the macula and detect subtle changes before you begin to notice any symptoms of problems. As a result, all patients taking plaquenil should have an examination approximately every six months. The macula should be examined through a dilated pupil. The incidence of Plaquenil related macular problems increases when approaching a dose of 600 to 700 mg. per day. It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Eye test for plaquenil toxicity frequency Plaquenil and eye exams" Lupus Community - Support Group, Plaquenil Side Effects on Your Eyes and Vision Lc3-ii vs lc3-i ratio chloroquineChloroquine phosphate testing kitArtemisinin and chloroquine structure Sep 13, 2019 uncontrolled eye movements; unsteadiness, trembling, or other problems with muscle control or coordination; vomiting; For Healthcare Professionals. Applies to hydroxychloroquine compounding powder, oral tablet. Cardiovascular. Frequency not reported Cardiomyopathy can result in fatal cardiac failure, biventricular hypertrophy. Dermatologic Plaquenil Side Effects Common, Severe, Long Term -. Conditions Plaquenil-related Eye Problems Eugene Eye Care. Stonewire Optometry-Blog-Hydroxychloroquine Why you need an eye exam. This test involves injecting dye into the arm followed by photographs of the back of the eye. Hydroxychloroquine damage can show up as a ring of damage around the central part of vision. If any problems are identified with testing at the hospital, you will be contacted directly by the ophthalmologist or a member of the eye care team. Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 For women, start with 100 pounds, and add 5 pounds for every inch over 5 feet. For men, start with 106 pounds, and add 6 pounds for every inch over 5 feet. The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight.