It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine prescribing information Hydroxychloroquine lupus panniculitis Hydroxychloroquine sulfate adverse effects Hydroxychloroquine in dogs She presented 3 months later with multiple skin lesions predominantly on her neck, bilateral forearms, and dorsal feet. The skin lesions were macular or patchy, some well and others poorly demarcated, with a hyperpigmentation of gray to black discoloration, generally annular, but some with irregular morphology. Hydroxychloroquine. What is Hydroxychloroquine? Hydroxychloroquine is an anti-malarial drug that is used to treat a wide variety of skin conditions. The way in which it works is unknown but it is understood to have anti-inflammatory effects. What is Hydroxychloroquine used for? May 21, 2010 I was diagnosed almost 2yrs ago with Lupus, SLE & subacute subcutaneous. The plaquenil made me lose my hair immediately. When it came back in most of it came in white which I read that the medicine can bleach your hair. Then last year I noticed areas on my legs that are brown or maybe it's that my skin has been bleached in areas and is very white. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Hydroxychloroquine and skin discoloration Hydroxychloroquine Skin Support, ACD A-Z of Skin - Hydroxychloroquine Chloroquine side effect homicidePlaquenil helping stomach inflammation Skin discoloration • Hair discoloration • Hair loss • Nausea • Vomiting • Abdominal pain. Other side effects of this drug Talk with your doctor right away if you have any of these signs of • Liver problems like dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin. Hydroxychloroquine Professional Patient Advice -. Plaquenil & skin discoloration -. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. A known side effect of using antimalarials long term is dark patches on the skin. The Lupus Encyclopedia Thomas Jr. 2014 says this 'One of the potential long-term side-effects of using anti-malarial medications such as hydroxychloroquine Plaquenil, chloroquine, and quinacrine is the development of dark-colored patches on the skin. We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female case 1 and a 78-year-old female case 2, both receiving 400 mg per day. Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated with hydroxychloroquine for 4-5 years.