MTX monotherapy (MTG) is recommended as (part of) first choice treatment but no head-to-head comparisons are available comparing MTX–HCQ CTG with MTG. RA patients from the Sint Maartenskliniek and Radboudumc Nijmegen who started MTX with or without concomitant HCQ from April 2010 to October 2015 were included. Chloroquine 500 mg Plaquenil and nephritis Chloroquine aralen Hydroxychloroquine have an eye examination every 6-12 months. Methotrexate. Methotrexate is one of the most commonly used corticosteroid-sparing therapies for sarcoidosis, due to its effectiveness, low cost and, at the dosages used to treat sarcoidosis, relatively low risk of side effects compared to other cytotoxic agents. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in. January 2, 2013. One Chick is looking for your advice on medication My Rheumatologist recommended Methotrexate for my RA which I haven’t started taking yet because I was waiting until after the holidays in case I have side effectshowever she mentioned Plaquenil but she felt the Methotrexate is better for my RA. Regression modelling was used to correct for confounding. The primary outcome was the between-group ΔDAS28-CRP at 6 months, and secondary outcomes were ΔDAS28-CRP at 12 months, EULAR response at 6 and 12 months, and treatment intensification. Methotrexate vs plaquenil Methotrexate and its benefit for Sjögren’s patients, Rheumatoid Arthritis Treatment Options Johns Hopkins. Plaquenil brand name covered by insuranceHydroxychloroquine schnitzler syndrome urticariaPlaquenil time to take effectPlaquenil dangers You just helped educate me. Thanks. I always thought that plaquenil was not a DMARD, but never bothered to look. I do know that plaquenil is generally considered the least invasive drug, generally prescribed as the first line of treatment. Methotrexate is the most commonly prescribed DMARD, but it does come with the chance of side-effects. Methotrexate or Plaquenil? DailyStrength. Member Discussions and Questions Advice Needed for.. Methotrexate vs Plaquenil? -. I haven't had any issues with Plaquenil, and I've been on it for 13 years. Be sure you get your eyes checked regularly for Plaquenil toxicity, a very rare side effect that can affect your vision, but is usually reversible if caught early. I know Plaquenil has helped me a ton, because I tried going off of it once to see if I really needed it. Jun 11, 2013 For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. May 28, 2016 I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems.