Chloroquine has been sporadically used in treating SARS-Co V-2 infection. Hydroxychloroquine shares the same mechanism of action as chloroquine, but its more tolerable safety profile makes it the preferred drug to treat malaria and autoimmune conditions. Plaquenil mefloquine Plaquenil retina damage Effect of chloroquine in pregnancy and breastfeeding Plaquenil dosage for lupus Annual screening may be commenced before 5 years of treatment if additional risk factors for retinal toxicity exist, such as concomitant tamoxifen therapy, impaired renal function eGFR less than 60 mL/minute/1.73 m 2 or high-dose therapy greater than 5 mg/kg/day of hydroxychloroquine sulfate. At the 2018 ACR/ARHP Annual Meeting, I had the opportunity to co-moderate this year's Great Debate, which was titled "Guidelines for SLE HCQ Dose Should Be No More Than 5 mg/kg In All Patients." Using the PBPK models, hydroxychloroquine concentrations in lung fluid were simulated under 5 different dosing regimens to explore the most effective regimen whilst considering the drug's safety profile. RESULTS Hydroxychloroquine EC50=0.72 μM was found to be more potent than chloroquine EC50=5.47 μM in vitro. Currently, there is no evidence to support the use of hydroxychloroquine in SARS-Co V-2 infection. We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-Co V-2 infected patients. Hydroxychloroquine dosing Plaquenil hydroxychloroquine sulfate dosing, indications., The 2018 ACR Great Debate Hydroxychloroquine Dosing for SLE Weight loss plaquenilDoes hydroxychloroquine help with psoriatic arthritis Generally, hydroxychloroquine is given in 200 mg or 400 mg doses, once per day. Higher doses can sometimes be used, but only in adults and not for all cases. RA and Hydroxychloroquine How Effective is it for Rheumatoid.. In Vitro Antiviral Activity and Projection of Optimized.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. Both adults and children should take one dose of hydroxychloroquine per week starting at least 1 week. before traveling to the area where malaria transmission occurs. They should take one dose per week while there, and for 4 consecutive weeks after leaving. The weekly dosage for adults is 310mg base 400mg salt. Oct 30, 2019 Dosage forms Variable daily dosing eg, alternating or skipping doses on certain days each week may be used to obtain the recommended dose for rheumatologic uses. All doses below are expressed as hydroxychloroquine sulfate salt. Hydroxychloroquine sulfate salt 200 mg is equivalent to hydroxychloroquine base 155 mg.