Chloroquine dosing retina recommendation

Discussion in 'Canadian Drug' started by iamgenius, 23-Feb-2020.

  1. WEB_Spb User

    Chloroquine dosing retina recommendation


    Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology.

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    Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy. Marmor MF1, Kellner U, Lai TY, Lyons JS, Mieler WF; American Academy of Ophthalmology. Author information 1Eye Institute at Stanford, Stanford University, Palo Alto, California, USA. Be commenced before five years of therapy if additional risk factors exist e.g. very high dose of drug therapy, concomitant Tamoxifen therapy or renal insufficiency. Adequate screening may not be possible with retinal co-pathology. Chloroquine appears to be more retinotoxic than hydroxychloroquine and so we recommend identical baseline Although the mechanisms of the two agents are presumed to be the same, many reports suggest that chloroquine is more toxic to the retina than hydroxychloroquine. The toxic dosage for chloroquine was derived from hydroxychloroquine retinal toxicity studies, although no definitive data have shown pharmacologic equivalence.

    While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula.

    Chloroquine dosing retina recommendation

    Hydroxychloroquine Plaquenil Toxicity and Recommendations for Screening, Hydroxychloroquine and Chloroquine Retinopathy.

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  5. Based on the present literature, in March 2016, new recommendations of the American Academy of Ophthalmology for ophthalmic screening tests in patients treated with chloroquine and hydroxychloroquine were published. These recommendations emphasized the fact that toxicity is related to the dose calculated by real weight.

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    Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the. Irreversible retinal damage observed in some patients; significant risk factors for retinal damage include daily doses of chloroquine phosphate 2.3 mg/kg of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate, and concurrent macular disease To prevent malaria, chloroquine tablets must be taken before, during, and after travel to a malaria zone. When treating the condition in adults, chloroquine is usually taken twice a day for one day and then once a day for two more days. A child's chloroquine dosage will be determined by his or her weight.

     
  6. beave User

    Download PDF Many systemic medications may cause retinal toxicity. Plaquenil Hydroxychloroquine Side effects, Images, Uses. Plaquenil Side Effects on Your Eyes and Vision Plaquenil and vision" Lupus Community - Support Group
     
  7. raut User

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Lupus Medications and Treatments Plaquenil Hydroxychloroquine for Lupus - LupusCorner Plaquenil Uses, Dosage & Side Effects -
     
  8. Ispanka XenForo Moderator

    Toxic Retinopathy With Hydroxychloroquine Therapy - JAMA Of 2361 patients who had taken hydroxychloroquine continuously for at least 5 years and who had 10-2 visual fields or SD-OCT, 177 7.5% showed clear signs of retinal toxicity. None of the primary medical indications for hydroxychloroquine therapy were significantly associated with an increased prevalence of retinal toxicity.

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  9. mf34xo Guest

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