If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range (/= 6.5 mg/kg/day). This graph shows various formulas that have been proposed for deriving ideal body weight for women, because virtually all cases of hydroxychloroquine toxicity have been female. Pictures of chloroquine tablets Chloroquine lysosomal acidification Chloroquine glycosylation Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Dosage is based on body weight. The typical. An audit of 100 patients seen at any of nine Canadian rheumatology clinics during early 2016 showed that 30% of patients were not on appropriate weight-based hydroxychloroquine dosages, and 13% of patients on the drug had not received a baseline retinal assessment during their first year of treatment, Sahil Koppikar, MD, reported in a poster. Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. The usual hydroxychloroquine dose that is prescribed is 400 mg/day. Weight based dosing plaquenil Ideal Body Weight for Calculating Hydroxychloroquine Dosage - The., Hydroxychloroquine dosage recommendations often ignored. Can you rheumate with plaquenilChloroquine adverse effects mnemonics Given the long half-life of hydroxychloroquine and the previously documented within day variations of less than 8% this was considered appropriate. All patients in the cohort were prescribed hydroxychloroquine not to exceed a dose of 6.5 mg per kilogram. The maximum daily dose prescribed is 400 mg. Hydroxychloroquine Blood Levels in SLE Clarifying dosing.. Plaquenil hydroxychloroquine sulfate dosing, indications.. Hydroxychloroquine Blood Levels in SLE Clarifying dosing controversies.. Clinical dosing of Plaquenil requires a negotiation between the patient’s rheumatologist and their eye care physician and is based, in part, on an individual patient’s weight, as well as risk factors for Plaquenil toxicity. It’s a careful balance that can require a deft hand and a little bit of forecasting. Melton & Thomas describe the typical safe Plaquenil dosage this way The usual dosage is two 200mg tablets per day. This is generally a "safe" dose for patients having a lean body weight of at least 135 lbs. The generally-regarded safe dosage is 6.5mg/kg/qd, thus the 135 lb. safety threshold. Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity.