One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil use during pregnancy Hydroxychloroquine ptsd Plaquenil muscle toxicity The bottom line is that the daily dose should be 5.0 mg per kg or less, using real body weight,” said Michael F. Marmor, MD, at Stanford University in Palo Alto, Calif. This represents a significant change from the 2011 guidelines, which recommended using ideal body weight to determine dosages. Rosenbaum discussed the guidelines from the American Academy of Ophthalmology AAO published in Ophthalmology. He reviewed the data which supports the use of the guidelines daily dose 5 mg/kg of actual body weight; a baseline eye exam; and eye exams at 5 years and annually thereafter. Nov 25, 2019 Initial dose 400 mg 310 mg base orally 1 to 2 times a day; this dose may be continued for several weeks or months, depending on patient response. Maintenance dose 200 to 400 mg 155 to 310 mg base orally daily. Comments -Each dose should be taken with a meal or a glass of milk. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Aao plaquenil dosing Drug spotlight on hydroxychloroquine Lupus Foundation of., The 2018 ACR Great Debate Hydroxychloroquine Dosing for SLE What drugs interact with plaquenilHow long does it take for plaquenil to workChloroquine diphosphate storagePlaquenil ophthalmology retina specialist 2018Chloroquine in congo The AAO published dosing and screening recommendations for chloroquine and hydroxychloroquine in 2016, revising previous recommendations published in 2011. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. The 2011 guidelines suggested a maximum dose of 6.5 mg/kg of ideal weight. Despite Plaquenil dosing recommendations, retinal toxicity.. Hydroxychloroquine Dosage Guide with Precautions -. The 2016 American Academy of Ophthalmology Hydroxychloroquine.. CONCLUSIONS Twenty-seven percent of cases of hydroxychloroquine retinopathy in obese women had ostensibly safe dosing based on 2016 AAO guidelines. Overdosing of obese women by 2016 AAO guidelines is not rare. Daily dosing based on the older 6.5-mg/kg ideal weight threshold is safer in women with a body mass index of 30 kg/m2 or more. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Summary of dosing guidelines. The new recommended daily dose of HCQ is less than 5 mg/kg of real weight, which has been shown to correlate better with risk than ideal weight. There is no similar demographic data for CQ, but older literature suggests less than 2.3 mg/kg real weight.