In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Hydroxychloroquine macular toxicity Hydroxychloroquine for lupus epocrates Each white-to-off-white, film-coated, peanut-shaped tablet with "PLAQUENIL" in black on one side contains 200 mg of hydroxychloroquine sulfate equivalent to 155 mg of base. Nonmedicinal ingredients black ink, calcium hydrogenophosphate, carnauba wax, corn starch, magnesium stearate, opadry White YS-I-7443, and polyethylene glycol 400. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate. corn starch, titanium dioxide USP, carnauba wax NF, shellac NF, black iron oxide NF. CLINICAL PHARMACOLOGY. Pharmacokinetics Following a single 200 mg oral dose of PLAQUENIL to healthy males, the. PLAQUENIL is indicated for the prophylaxis of. Dark spots in your mouth can be caused by a variety of things. They run from minor lesions, such as a stain from a dental filling that leaked into your gums called an amalgam tattoo, to benign tumors of your blood vessels, such as a hemangioma. Some types of cancer can also show up as dark spots. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Plaquenil and black gums The Risk of Retinal Toxicity with Plaquenil, PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION Hydroxychloroquine sulfate solubilityBlackrock hydroxychloroquine Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Dark Spot in the Mouth — Is It Cancer? - Oral, Head, and.. Dental Concerns - Lupus International. Answer. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Inflammation associated with gum disease may stimulate inflammation in other parts of the body or complicate other diseases, such as cardiovascular disease, kidney disease, diabetes, or certain forms of cancer. Michael Richards, 45, of Prattville, AL, was diagnosed with lupus in 1987, but had problems with her mouth and gums before that. Teeth or gum problems, related to Lupus? deleted_user 05/22/2011. This may be a silly question but does anyone have problems with their gums from Lupus? My gums in my mouth have been getting inflamed and sore. never had a problem with them before. Have had 4 teeth pulled though.