It is a polymorphic ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram (ECG). Symptoms and consequences include palpitations, dizziness, lightheadedness (during shorter episodes), fainting (during longer episodes), and sudden cardiac death. Torsades occurs as both an inherited (linked to at least 17 genes) Common causes for torsades de pointes include drug-induced QT prolongation and less often diarrhea, low serum magnesium, and low serum potassium or congenital long QT syndrome. G6pd hydroxychloroquine Plaquenil altitude sickness Cardiac arrhythmias, conduction disorders such as bundle branch block / atrio-ventricular block, QT interval prolongation, torsade de pointes, ventricular tachycardia and ventricular fibrillation have been reported with therapeutic doses of Chloroquine as well as with overdose. The risk is greater if Chloroquine is administered at high doses. Foscarnet has been associated with postmarketing reports of both QT prolongation and torsade de pointes TdP. Chloroquine administration is also associated with an increased risk of QT prolongation and TdP. If these drugs are administered together, obtain an electrocardiogram and electrolyte concentrations before and periodically during treatment. Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments-If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate 600 mg base may be taken orally in 2 divided doses, 6 hours apart. Certain drugs and combinations of drugs resulting in drug interactions are common contributors to torsades de pointes risk. It can be seen in malnourished individuals and chronic alcoholics, due to a deficiency in potassium and/or magnesium. Chloroquine torsades DRUGS TO BE AVOIDED BY CONGENITAL LONG QT PATIENTS, Chloroquine Phosphate chloroquine phosphate dose, indications. Hydroxychloroquine and loratadineKeflex and plaquenilOmeprazole and plaquenil QT interval prolongation, torsades de pointes, and ventricular arrhythmias reported; risk is greater if chloroquine is administered at high doses; fatal cases reported; use with caution in patients with cardiac disease, a history of ventricular arrhythmias, uncorrected hypokalemia and/or hypomagnesemia, or bradycardia 50 bpm, and during. Aralen, Chloroquine phosphate chloroquine dosing, indications.. Chloroquine Dosage Guide with Precautions -. Drug-induced QT prolongation and Torsades de Pointes - the.. Chloroquine Nivaquine was the first drug used for the treatment of malaria. It is effective against the blood stages of the malaria parasite and penetrates into most tissues. It is effective against Plasmodium ovale and malaria and susceptible strains of vivax and falciparum. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The most important thing to mention about the management of torsade de pointes is that there is essentially no evidence. The best available evidence is for the standard ACLS algorithm, with no differentiation made between torsades and standard monomorphic ventricular tachycardia.