Retinal toxicity of hydroxychloroquine

Discussion in 'Chloroquin' started by Support LinkRU, 24-Feb-2020.

  1. xTRAFFIC Well-Known Member

    Retinal toxicity of hydroxychloroquine


    In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio.

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    Ocular side effects of hydroxychloroquine can include impact on the cornea, ciliary body, lens and retina. 1 Corneal deposits, fortunately, rarely affect vison. 2 However, the concern of retinal toxicity and the need for monitoring must be reviewed with patients prior to and during its use. 2,3 Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. Retinal toxicity related to hydroxychloroquine in patients with systemic lupus erythematosus and rheumatoid arthritis. Telek HH, Yesilirmak N, Sungur G, Ozdemir Y, Yesil NK, Ornek F. Doc Ophthalmol. 2017 Dec; 1353187-194.

    As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits.

    Retinal toxicity of hydroxychloroquine

    Rx Side Effects New Plaquenil Guidelines and More - American Academy., Chloroquine retinopathy - Wikipedia

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  6. AT A GLANCE • Long-term use of hydroxychloroquine sulfate may result in parafoveal retinal toxicity. • No single imaging platform can confirm the presence of hydroxychloroquine toxicity. • Microperimetry and adaptive optics are undergoing studies to confirm their usefulness in.

    • Retina Today - Imaging in Hydroxychloroquine Toxicity April 2019.
    • Chloroquine And Hydroxychloroquine Toxicity - StatPearls..
    • Hydroxychloroquine Retinal Toxicity..

    Factors that increase the risk of developing hydroxychloroquine associated retinal toxicity include daily dose, cumulative dose, renal or liver impairment, older age, and prior retinal disease. Specifically, a daily dose of 6.5mg/kg based on ideal body weight and a cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine are both considered risk factors for retinal toxicity. Hydroxychloroquine-Induced Retinal Toxicity Symptoms and Signs. Patients in earlier stages of hydroxychloroquine retinal toxicity usually do not. Mechanism of Toxicity. The mechanism of hydroxychloroquine retinal toxicity has yet. Medication Dosage. Several factors have been associated with. Retinal toxicity is a very rare side effect of the hydroxychloroquine therapy, but when it has occurred, vision loss may be permanent and may progress even years after the cessation of medication. Patients would be examined every 3 months, then annually, until they are stabled.

     
  7. qazex New Member

    I've been sick with a cold and my symptoms are getting worse. I would seek help when I felt bad, they would blame it on stress or something, I would get to feeling better and back off. Common and Rare Side Effects for Plaquenil Oral Lupus and Tremors. DailyStrength How lupus shaking affects other body parts? Dr Garys Lupus.
     
  8. MIkeApp Moderator

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  9. Sergey-SEO Guest

    Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Headache inability to move the eyes increased blinking or spasms of the eyelid joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs loss of hearing lower back or side pain noisy breathing painful or difficult urination red irritated eyes

    Is extreme fatigue a side effect of Plaquenil?
     
  10. komdus Guest

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