Chloroquine and primaquine combination

Discussion in 'Chloroquine Drug' started by dennis_ru, 20-Mar-2020.

  1. winseo Well-Known Member

    Chloroquine and primaquine combination


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

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    The research, published in PLOS Medicine supports recommendations that these artemisinin-based combination therapies ACT should be combined with primaquine. Resistance of Plasmodium vivax malaria parasites to chloroquine – the most commonly used antimalarial drug – is increasing around the world, threatening malaria control and elimination efforts. In most countries with endemic P. vivax, the preferred first-line radical treatment for P. vivax remains chloroquine, combined with 7- to 14-day primaquine regimens, and this has barely changed since the 1950s. Chloroquine and primaquine were not available in a single fixed-dose combination tablet until December 1969, when regulatory approval of combination tablets manufactured by Sanofi-Synthelabo was the first major accomplishment of the Division of Experimental Therapeutics at Walter Reed Army Institute of Research, established in 1961 to develop new antimalarial drugs.

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Chloroquine and primaquine combination

    Chloroquine Aralen - Side Effects, Dosage, Interactions., Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based.

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  7. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus.

    • Chloroquine - Wikipedia.
    • Role of US Military Research Programs in the Development..
    • CDC - Malaria - Diagnosis & Treatment United States..

    Combination therapy with antimalarial drugs is the simultaneous use of two or more blood schizontocidal drugs with independent modes of action and different biochemical targets in the parasite. The concept of combination therapy is based on the synergistic or additive potential of two or more drugs. Primaquine phosphate is 8-4-Amino-1-methylbutylamino-6-methoxyquinoline phosphate, a synthetic compound with potent antimalarial activity. Each tablet contains 26.3 mg of Primaquine phosphate equivalent to 15 mg of primaquine base. The dosage is customarily expressed in terms of the base. Primaquine is used after other medications such as chloroquine have killed the malaria parasites living inside red blood cells. Primaquine then kills the malaria parasites living in other body.

     
  8. YSAq Well-Known Member

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  9. Darynthium Well-Known Member

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    Hydroxychloroquine Uses, Dosage & Side Effects -