Chloroquine resistance transporter structure

Discussion in 'Chloroquine Pills' started by gelous, 03-Mar-2020.

  1. FuRi User

    Chloroquine resistance transporter structure


    This score cannot be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry.

    Hydroxychloroquine side effects and alcohol Replacement for hydroxychloroquine

    Hide 10 20 30 40 50 mkfaskknnq knsskndery reldnlvqeg ngsrlgggsc lgkcahvfkl 60 70 80 90 100 ifkeikdnif iyilsiiyls vcvmnkifak rtlnkignys fvtsethnfi 110 120 130 140 150 cmimffivys lfgnkkgnsk erhrsfnlqf faismldacs vilafigltr 160 170 180 190 200 ttgniqsfvl qlsipinmff cflilryryh lynylgavii vvtialvemk 210 220 230 240 250 lsfetqeens iifnlvlisa lipvcfsnmt reivfkkyki dilrlnamvs 260 270 280 290 300. And that’s what is so exciting about the image above. It presents the unprecedented, 3D atomic-resolution structure of a protein made by P. falciparum that’s been a major source of its resistance the chloroquine-resistance transporter protein, or PfCRT. In this cropped density map, you see part of the protein’s biochemical structure. Chloroquine CQ is a widely used antimalarial agent, but the emergence and spread of CQ-resistant parasites is a growing global health problem. Although its physiological relevance remains unknown, P. falciparum CQ resistance transporter PfCRT confers CQ resistance through CQ egress from digestive vacuoles of P. falciparum. To address this issue, recombinant CQ-sensitive or CQ-resistant PfCRT proteins were purified and their transport activities were assessed.

    This is known as the 'taxonomic identifier' or 'taxid'. This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) AF030694 Genomic DNA Translation: AAF26926.1AF233064 m RNA Translation: AAF60271.1AF233065 m RNA Translation: AAF60272.1AF233066 m RNA Translation: AAF60273.1AF233067 m RNA Translation: AAF60274.1AF233068 m RNA Translation: AAF60275.1AF495376 Genomic DNA Translation: AAO85506.1AF495377 Genomic DNA Translation: AAO85507.1AF495378 Genomic DNA Translation: AAO85508.1AY651315 m RNA Translation: AAU00067.1AF468006 m RNA Translation: AAL75580.1DQ156107 m RNA Translation: AAZ81606.1DQ156108 m RNA Translation: AAZ81607.1DQ156109 m RNA Translation: AAZ81608.1DQ533840 m RNA Translation: ABF82363.1AY254700 m RNA Translation: AAP79044.1AF030694 Genomic DNA Translation: AAF26926.1AF233064 m RNA Translation: AAF60271.1AF233065 m RNA Translation: AAF60272.1AF233066 m RNA Translation: AAF60273.1AF233067 m RNA Translation: AAF60274.1AF233068 m RNA Translation: AAF60275.1AF495376 Genomic DNA Translation: AAO85506.1AF495377 Genomic DNA Translation: AAO85507.1AF495378 Genomic DNA Translation: AAO85508.1AY651315 m RNA Translation: AAU00067.1AF468006 m RNA Translation: AAL75580.1DQ156107 m RNA Translation: AAZ81606.1DQ156108 m RNA Translation: AAZ81607.1DQ156109 m RNA Translation: AAZ81608.1DQ533840 m RNA Translation: ABF82363.1AY254700 m RNA Translation: AAP79044.1 This subsection of the 'Entry information' section provides a mnemonic identifier for a Uni Prot KB entry, but it is not a stable identifier. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'. This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein.

    Chloroquine resistance transporter structure

    RCSB PDB - 6UKJ Single-Particle Cryo-EM Structure of Plasmodium., Chloroquine-resistance transporter – NIH Director's Blog

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  4. A recent study of the P. falciparum chloroquine-resistance transporter points to mechanisms underlying resistance to chloroquine and piperaquine Hilary Hurd Electron micrograph of red blood cells infected with Plasmodium falciparum.

    • Malaria understanding drug resistance - BugBitten.
    • Plasmodium falciparum chloroquine resistance transporter..
    • The principal chloroquine resistance protein of Plasmodium falciparum..

    The compound also potentiated the activity of vinblastine in an MDR cell line approximately 90-fold, indicating it may inhibit the P-gp transporter. WR268954 10, a pyrrolidino alkyiamine, decreases the IC 50 of chloroquine for drug resistant P. falciparum 90-fold when compared to chloroquine alone 98. Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a 5-diethylaminopentan-2-ylamino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. Mar 17, 2015 Plasmodium falciparum chloroquine resistance transporter is a H +-coupled polyspecific nutrient and drug exporter Narinobu Juge, a, b Sawako Moriyama, c Takaaki Miyaji, a Mamiyo Kawakami, c Haruka Iwai, c Tomoya Fukui, c Nathan Nelson, d Hiroshi Omote, c, 1 and Yoshinori Moriyama a, c, 1

     
  5. qprst Moderator

    This may be the result of a broken link, expired bookmark, or mistyped URL. Systematic review of hydroxychloroquine use in pregnant. Follow-Up of Infants Exposed to Hydroxychloroquine Given to Mothers. The use of hydroxychloroquine in lupus pregnancy the British.
     
  6. Booger man Well-Known Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Chloroquine definition and meaning Collins English Dictionary Chloroquine Article about Chloroquine by The Free Dictionary Chloroquine Definition of Chloroquine at
     
  7. bliZZZ Guest

    Oral Concerns in People With Lupus Oral Concerns in People With Lupus. Oral Concerns in People With Lupus. Adapted from a presentation at the SLE Workshop at Hospital for Special Surgery. Related Content

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  8. HeebyWawgab Guest

    Hydroxychloroquine An old drug with new relevance. Benefit in rheumatoid arthritis. Though there is less evidence, hydroxychloroquine has also shown benefit in rheumatoid arthritis, where it can be used by itself in mild disease or as part of combination therapy with active arthritis. Compared with biologic therapy in patients with early aggressive rheumatoid arthritis.

    Potential Effect of Hydroxychloroquine in Diabetes Mellitus.