Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Can plaquenil make you tired What interactions can occur if you take plaquenil and alcohol Plaquenil generic ingredients Diarrhea from hydroxychloroquine sulfate Plaquenil lowers your immune system’s ability to cause inflammation. This can help control symptoms like rashes, skin and mouth sores and joint pain. Plaquenil and your eyes. A rare side effect of Plaquenil is damage to the eye's retina. The retina is the light-sensitive tissue at the back of the eye. Using Plaquenil for a long period of time. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. The side effect that is of greatest concern is retinal toxicity. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil side effect skin Plaqunil rash -, Plaquenil Side Effects on Your Eyes and Vision Effects of plaquenil on the eyesPlaquenil and mycophenolate Side Effects of Plaquenil. Antimalarial medications are typically well tolerated. Nearly 90% of people will not experience any side effects from these types of medications. Call your doctor right away if you notice any of these side effects Blurred vision or changes in your vision Plaquenil Hydroxychloroquine for Lupus - LupusCorner. The Risk of Retinal Toxicity with Plaquenil. Will you have Dry skin with Plaquenil - eHealthMe. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Tell your doctor if any of the following side effects, as they may be indications of a more serious reaction Headache. Loss of appetite. Dizziness. Nausea. Diarrhea, vomiting, or stomach pain. Skin rash. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong.