Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Chloroquine phosphate and alcohol Hydroxychloroquine mechanism of action lupus Hydroxychloroquine myositis Is hydroxychloroquine used for pain Scleroderma is a long-lasting autoimmune disease that affects your skin, connective tissue, and internal organs. Learn more about the types, causes, risk factors, symptoms, diagnosis, treatment. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Localized scleroderma is a rare autoimmune disease with primary affection of the skin, and occasional involvement of the fat tissue, muscle, fascia, and bone. Depending on the clinical subtype, the spectrum of skin lesions ranges from singular plaque lesions to severe generalized or linear subtypes. which may lead to movement restrictions and permanent disability. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Plaquenil scleraderma Scleroderma symptoms, treatments & forums PatientsLikeMe, Plaquenil Uses, Dosage & Side Effects - Plaquenil cut in halfCan i tan on plaquenilCan plaquenil affect thyroid Scleroderma News is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Scleroderma News Home - Scleroderma News. Morphea Localized Scleroderma - Dermatology Advisor. Scleroderma - Wikipedia. Although the medical research community has not come up with any "Proof" that Plaquenil is effective - there are many, many, many people in both the scleroderma & lupus communities who will tell you that Plaquenil was THE drug that helped with symptom relief over the long term with little to no side effects. Oct 09, 2015 Hi, I have Raynaud's syndrome since 2010, and in 2014 I had a blood test with the result of positive ANA speckled and ACA, ACA-B. I still don't have thickening skin of the hands/fingers, but my doctors told me I have Limited Systemic Scleroderma, since anti centromere antibody ACA is a very specific scleroderma auto-antibody. Hi Maddy, My rheumatologist does consider Plaquenil to be a disease modifying drug. They truly don't know exactly how it works. It does reduce the pain and fatigue and has the ability to "stop the disease in its track and keep it from progressing" Those are my rheumatologist's exact words.