Norwich, New York of the Excellence in Geriatric Pharmacy Practice Award from the Commission for Certification in Geriatric Pharmacy. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Malaria treated with chloroquine Prophylaxis for malaria in chloroquine resistant area Drugs that lower the seizure threshold 2 A W Hitchings e.g. benzodiazepines; antagonising glutamate at AMPA receptors e.g. perampanel; and a combination of these effects e.g. valproate. Drugs with the opposite effects may induce seizures. The propensity of a drug to induce seizures depends on its effects on neurotransmission and their time- Hydroxychloroquine can lower the seizure threshold; therefore, the activity of antiepileptic drugs may be impaired with concomitant use. Azithromycin Major Avoid coadministration of hydroxychloroquine and azithromycin. Hydroxychloroquine increases the QT interval and should not be administered with other drugs known to prolong the QT interval. Aug 14, 2017 Tramadol, a powerful narcotic pain reliever, can lower the seizure threshold, reports the medical reference website The likelihood of seizures associated with tramadol use increases in patients concurrently taking antidepressants, antipsychotic medications and other narcotics. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Plaquenil lower seizure threshold What causes seizures?, Plaquenil hydroxychloroquine sulfate dose, indications. Quinacrine with hydroxychloroquine lupus profundus Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be compliant with their anticonvulsant drug regimen. Medications that lower seizure threshold include the antidepressant and nicotinic antagonist bupropion. Seizure threshold - Wikipedia. Drugs That Lower the Seizure Threshold Healthfully. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Feb 24, 2008 Because I have epilepsy I have a lowered seizure threshold, so various drugs can be more problematic - then again, I am often able to take them without a problem, particularly at lower doses etc etc. The classic drug for interacting is coumadin, as those of us who are on it know only two well. It interacts with practically everything. Aug 02, 2019 - Updated on August 2, 2019 By Dr. Artour Rakhimov, Alternative Health Educator and Author. A proper understanding of epilepsy, seizures, seizure threshold and brain abnormalities during seizures should be based on knowledge of what is going on in the nerve cells during their normal work. Insulin Or Antidiabetic Drugs-As PLAQUENIL may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin may be required. •Drugs That Prolong QT Interval And Other Arrhythmogenic Drugs •PLAQUENIL can lower the seizure threshold.