Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil brand name cost What stage of infection did the chloroquine treat Oct 21, 2010 Introduction. The use of hydroxychloroquine HCQ, an antimalarial drug utilized for a range of rheumatologic and dermatologic diseases, is associated with a low incidence of retinopathy 0.5% when used at recommended doses 6.5 mg/kg per day.1 It has largely replaced chloroquine because of decreased ocular toxicity at high dosages,2 but can still lead to potentially irreversible visual loss. Aug 06, 2014 Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Plaquenil comes in 200 milligram mg tablets that are taken by mouth. To prevent malaria in adults, two tablets are typically taken once a week, on the same day each week. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil et oct Retina Today - Evaluating Hydroxychloroquine Toxicity With., Multimodal Imaging in Plaquenil Toxicity Can plaquenil ever be stopped abruptly SD Spectral Domain OCT With early Hydrochloroquine retinopathy, SD-OCT can detect outer layer retinal abnormalities Specifically, SD-OCT can detect loss of the perifoveal photoreceptor inner segment/outer segments line PIL At the macula, an ovoid appearance can appear described as “flying saucer” sign by Chen, et al18 ILM IPL OPL Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Plaquenil hydroxychloroquine sulfate dose, indications.. To report expanded SD-OCT findings of HCQ retinopathy that may assist the clinician in earlier diagnosis. To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. Setting Private practice and academic institution. Patient Population Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed. An initial fundus evaluation of the macula is critical to rule out preexisting disease that might make the retina more susceptible or screening difficult. Baseline visual fields VFs and spectral-domain optical coherence tomography SD-OCT scans are useful but not essential, unless abnormalities are present at baseline. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.