It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine plus primaquine Plaquenil related toxicity That combination is working very well for me. The plaquenil can.that I mean that it can really make you feel worn down, tired and weepy, I had depression when I started taking it. Since you are dealing with depression anyway, please be aware of this possibility. Taking B12 or even getting B12 injections can help a lot with this problem." In rare cases, Plaquenil can cause cardiomyopathy, a chronic disease of the heart muscle. If you're taking Plaquenil for an autoimmune condition, your symptoms should begin to improve after a few. Aug 14, 2017 Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Can plaquenil cause tiredness Does Plaquenil cause fatigue or fever? - Rheumatoid Arthritis, Plaquenil Hydroxychloroquine - Side Effects, Dosage. Methotrexate and plaquenil interactionPlaquenil 500 mg efectos a largo plaxo Jun 21, 2015 Hydroxychloroquine Plaquenil and generics can itself cause fatigue in some users, it can interrupt sleep patterns especially by causing more vivid dreams which in turn makes one more tired. The drug can also lower blood counts red cell, white cells and others too which in turn can cause fatigue. Is lethargy and tiredness a side effect of hydroxychloroquine?. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. It is unusual for plaquenil to cause muscle weakness, although it has been reported. I do not know what other medications your taking, which might have similar side effects. It is much more common to cause fatigue and ataxia, which might be mistaken for muscle weakness, but I will assume that your experiencing muscle weakness. You expect to feel tired if you take a sleeping pill, but other kinds of medications can cause fatigue, too. It’s one of the most common side effects of prescription and over-the-counter. Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. Medications That Make You Tired. Common culprits and what you can do. Pharmacy and Medication Tips.