Why chloroquine is given in loading dose

Discussion in 'Trusted Online Pharmacy' started by ddust, 25-Feb-2020.

  1. booch Moderator

    Why chloroquine is given in loading dose


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine enters the red blood cell, inhibiting the parasite cell and digestive vacuole by simple diffusion. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. These findings support the idea that a loading dose of 20 mg/kg given at intervals during the first 12 h is well tolerated and can be used to obtain a more rapid decrease in parasitemia and to shorten the treatment time of uncomplicated chloroquine-susceptible falciparum malaria in the field. Why administer a vancomycin loading dose? Due to the pharmacokinetics of vancomycin, a loading dose – a large dose given once at the onset of therapy to rapidly achieve a therapeutic drug concentration in the body – is required to ensure that vancomycin levels are not subtherapeutic at the beginning of treatment. 6,7

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Why chloroquine is given in loading dose

    Chloroquine for Malaria in Pregnancy - Full Text View., Efficacy of a loading dose of oral chloroquine in a 36-hour.

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  5. Chloroquine shouldn’t be utilized in these circumstances except the profit to the affected person outweighs the potential risks. Why chloroquine is given as a loading dose. The key mutation seems to be K76T since no chloroquine resistant isolate carries the wild sort lysine at position 76.

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    Maintenance dose is calculated from desired peak concentration multiplied by the clearance rate. Loading dose is the desired peak concentration multiplied by the volume of distribution. A loading dose rapidly achieves the peak concentration necessary to compete with clearance, so that the desired effect is achieved and maintained sooner. Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments-If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate 600 mg base may be taken orally in 2 divided doses, 6 hours apart. Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver.

     
  6. Vitalik_82 New Member

    It is an Fc receptor which facilitates the transcytosis of the soluble polymeric isoforms of immunoglobulin A , and immune complexes. Rheumatoid Arthritis Treatment Options Johns Hopkins. ICD-10-CM Diagnosis Code Z79.899 Other long term. Antimalarials in IgA Nephropathy Did Our Supportive.
     
  7. Mesejuite XenForo Moderator

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Chloroquine Oral Uses, Side Effects, Interactions. Addgene Lentivirus Production Protocol Chloroquine - FDA prescribing information, side effects.
     
  8. ainf XenForo Moderator

    Chloroquine - FDA prescribing information, side effects and uses Oct 01, 2018 Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus.

    Quinine and chloroquine - ScienceDirect