Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil for granuloma annulare Plaquenil help with fatigue Ranitidine is an H2 histamine-2 blocker, which decreases the amount of acid created by the stomach. Over-the-counter Ranitidine is approved to prevent and relieve heartburn associated with acid. If you have psoriasis, chloroquine Aralen and hydroxychloroquine Plaquenil can cause problems. Other Medicines That Might Trigger a Flare. A few other drugs to discuss with your doctor include The plaquenil has caused a weight gain of about 20-25 pounds for me. Since I was diagnosed with MCTD a year ago, Plaquenil has been the only medication besides eye supplements, thyroid meds - been stable for years, and most recently Evoxac that I have been given. Hydroxychloroquine may also be used for purposes not listed in this medication guide. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil and zantac Hydroxychloroquine Plaquenil, Drugs & Medications That Can Trigger Psoriasis Flare-Ups Hydroxychloroquine regular blood test The study is based on ranitidine hydrochloride and hydroxychloroquine sulfate the active ingredients of Zantac and Plaquenil, respectively, and Zantac and Plaquenil the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. Zantac and Plaquenil drug interactions - eHealthMe. Plaquenil & Weight Gain/Loss. Plaquenil and antacids?. Zantac's risk appears to be the unstable nature of the drug itself, said Valisure CEO David Light. “This isn’t some new, bad manufacturing process overseas like what happened with valsartan. Can I take zantac while taking methotrexate and plaquenil? Asked by margmac Updated 13 January 2015 Topics plaquenil, zantac, rheumatoid arthritis, methotrexate, antacid, stomach, contraindication Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD. It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms.