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Viagra originally developed for

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    Viagra originally developed for


    Some of the best inventions and discoveries in the history of civilization have been accidental. Penicillin, Teflon, radioactivity, even your favourite Coca-Cola were all chance discoveries. An accidental invention is one where scientists are trying to find a solution to problem A but chance upon a solution to problem B. This is exactly what happened in the case of mankind's dearly loved drug Viagra, that treats erectile dysfunction. In 1989, chemists at Pfizer's research centre in Kent, England, were working to find a new drug to treat hypertension and angina pectoris (chest pain due to blocked arteries). A new compound that was named Sildenafil (UK92480) was created and subsequently tested on a group of men. Unfortunately, in the clinical trials, the compound failed to have a desired effect on hypertension and did not help in dilating the muscles in the heart. zoloft quit working In 1953 Dr Norm Larsen, founder of the Rocket Chemical Company, was trying to create a fluid which would prevent nuclear missiles from going rusty. There’s lots of waiting around in a Cold War, and the US government found that their arsenal wasn’t faring well. A group of scientists working at Pfizer's lab in Kent developed a drug called Sildenafil for the treatment of angina. Clinical trials in Swansea found that it had almost no effect on the heart or angina, but quite a pronounced side effect on another organ. Cue a quick brainstorming session by the marketing department, and Viagra soon went on sale across the globe. In 2008, the peak sales year for the drug, Pfizer sold almost $2bn worth of the stuff. The patent has now expired in much of Europe, allowing rival companies to sell their own versions.

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    Nov 30, 2017. However, young men who use Viagra as a lifestyle drug can harm their potency, because they begin to doubt their virility without it, and develop. buy prednisone 1mg Sildenafil the active ingredient in Viagra was originally developed as a blood pressure medication before it was ever used to treat ED. In fact, erections were. Sep 10, 2017. Sildenafil, the active ingredient in Viagra, was originally developed to treat cardiovascular problems. It was meant to dilate the heart's blood.

    The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Ten years ago this month, the Food and Drug Administration's approval of a little blue pill changed the sex lives of millions of men and women. Viagra, the first oral treatment for erectile dysfunction was developed accidentally by scientists at Pfizer Laboratories and was greenlighted for use by the FDA on March 27, 1998."Originally, we were testing sildenafil, the active drug in Viagra, as a cardiovascular drug and for its ability to lower blood pressure,'' Dr. Brian Klee, senior medical director at Pfizer, told French news agency, AFP. "But one thing that was found during those trials is that people didn't want to give the medication back because of the side effect of having erections that were harder, firmer and lasted longer.'' Since its approval, Viagra has been used by 35 million men around the world. It took the taboo out of impotence — former presidential candidate Bob Dole who suffered from erectile dysfunction after surgery for prostate cancer once appeared in a commercial for the drug — and made it easier to treat.

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    BBC News - Viagra and other drugs discovered by accident, What are Common Side Effects of ED Medication? - Impatient - Roman

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  7. Aug 3, 2018. One of mankinds most dearly loved drug Viagra was an accidental discovery and one that became lifechanging for a lot of men and women.

    • How Viagra Was Invented Accidentally -
    • How Viagra was discovered by Pfizer — Quartz
    • Hugely Successful Products Originally Invented for Something Else.

    Mar 27, 2008. Professor Meika Loe is an expert on Viagra, the first oral. and produced using a proprietary transcription process developed with NPR. prednisolone topical Oct 20, 2014. Viagra was originally tested for heart problems – angina pectoris, a chest pain associated with coronary heart disease – on the basis of its. Mar 27, 2013. Wednesday marks the 15th anniversary of Viagra's FDA approval in the. But how did a drug that was originally tested for the treatment of heart.

     
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