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Viagra originally developed for

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  1. swaru XenForo Moderator

    Viagra originally developed for


    Some of the best inventions and discoveries in the history of civilization have been accidental. Penicillin, Teflon, radioactivity, even your favourite Coca-Cola were all chance discoveries. An accidental invention is one where scientists are trying to find a solution to problem A but chance upon a solution to problem B. This is exactly what happened in the case of mankind's dearly loved drug Viagra, that treats erectile dysfunction. In 1989, chemists at Pfizer's research centre in Kent, England, were working to find a new drug to treat hypertension and angina pectoris (chest pain due to blocked arteries). A new compound that was named Sildenafil (UK92480) was created and subsequently tested on a group of men. Unfortunately, in the clinical trials, the compound failed to have a desired effect on hypertension and did not help in dilating the muscles in the heart. how old do you have to be to buy cytotec In 1953 Dr Norm Larsen, founder of the Rocket Chemical Company, was trying to create a fluid which would prevent nuclear missiles from going rusty. There’s lots of waiting around in a Cold War, and the US government found that their arsenal wasn’t faring well. A group of scientists working at Pfizer's lab in Kent developed a drug called Sildenafil for the treatment of angina. Clinical trials in Swansea found that it had almost no effect on the heart or angina, but quite a pronounced side effect on another organ. Cue a quick brainstorming session by the marketing department, and Viagra soon went on sale across the globe. In 2008, the peak sales year for the drug, Pfizer sold almost $2bn worth of the stuff. The patent has now expired in much of Europe, allowing rival companies to sell their own versions.

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    Sep 25, 2018. Originally a medication developed by Pfizer to treat angina pectoris chest. Pfizer called it Viagra and made tens of billions of dollars over the. i need amoxicillin From Velcro to Viagra 10 products that were invented by accident. Clinical trials at the pharmaceutical company Pfizer had originally studied Viagra's use as a. Jan 26, 2012. 6 Hugely Successful Products Originally Invented for Something Else. Viagra, or Sildenafil, as it's officially known, was originally conceived as.

    The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Ten years ago this month, the Food and Drug Administration's approval of a little blue pill changed the sex lives of millions of men and women. Viagra, the first oral treatment for erectile dysfunction was developed accidentally by scientists at Pfizer Laboratories and was greenlighted for use by the FDA on March 27, 1998."Originally, we were testing sildenafil, the active drug in Viagra, as a cardiovascular drug and for its ability to lower blood pressure,'' Dr. Brian Klee, senior medical director at Pfizer, told French news agency, AFP. "But one thing that was found during those trials is that people didn't want to give the medication back because of the side effect of having erections that were harder, firmer and lasted longer.'' Since its approval, Viagra has been used by 35 million men around the world. It took the taboo out of impotence — former presidential candidate Bob Dole who suffered from erectile dysfunction after surgery for prostate cancer once appeared in a commercial for the drug — and made it easier to treat.

    Viagra originally developed for

    Discovered by Accident, Viagra Still Popular 10 Years Later Fox News, From Velcro to Viagra 10 products that were invented. - History Extra

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  7. Feb 16, 2007. Say the name Viagra and most people will automatically think of a drug to. This is not altogether surprising given that Viagra was originally.

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    Aug 3, 2018. One of mankinds most dearly loved drug Viagra was an accidental discovery and one that became lifechanging for a lot of men and women. prednisolone and cats Nov 30, 2017. However, young men who use Viagra as a lifestyle drug can harm their potency, because they begin to doubt their virility without it, and develop. Sep 10, 2017. Sildenafil, the active ingredient in Viagra, was originally developed to treat cardiovascular problems. It was meant to dilate the heart's blood.

     
  8. PHWizard Moderator

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    Each and every year around this time, thousands of churches around the country participate in an organization called Operation Christmas Child. If you are unfamiliar with Operation Christmas Child, the gist is this: churches distribute pre-printed shoebox-sized cardboard boxes, which are then filled by families with toys, trinkets, and basic necessity items like toothbrushes and shipped off to children in non-first world countries so they can have something to open at Christmas time. What I know now that I didn’t know then is that are many, may reasons NOT to participate in Operation Christmas Child, and many alternative organizations you can support that will offer you the opportunity to both truly help someone in need and teach your children about generosity and global poverty, all at the same time. Supporting Operation Christmas Child means supporting the “ministry” of Franklin Graham. Many churches I attended throughout my formative years participated in Operation Christmas Child, and many years my family and I dutifully picked up a few shoeboxes and went to the Dollar General in search of what we thought would bring poor children around the world happiness and joy. And Franklin Graham, son of famed evangelist Billy Graham, appears to be making a valiant attempt to go down in history as the Donald Trump of theology. In the three years since I originally published this piece, he formally endorsed Trump’s campaign for presidency and has spent a huge chunk of internet bandwidth defending the administration’s every horrifying move. His Facebook and Twitter feeds are a never-ending font of racist, sexist, homophobic, transphobic, xenophobic and otherwise bigoted vitriol. Most of what he has to say is so nonsensically hateful it doesn’t bear repeating—but just to name a few recent doozies, Graham has called for Muslims to be barred from entering the United States, boldly proclaimed that the police-enforced lynching of black and brown men and women by the state is a result of their failure to comply with orders, led hundreds of thousands of followers in a boycott of Target not once but twice in an attempt to bully the company into conformity with his conservative gender roles and sexual ethic, and so many more—and much worse—things. He even recently went out of his way to defend Judge Brett Kavanaugh, a man credibly accused of attempted sexual assault, violent alcohol use, and participating in gang rape activities. MSU @michiganstateu Twitter side effects of methylprednisolone What to do if your erectile dysfunction medication isn't working - Dr Fox Pink Viagra’ Approved by FDA 5 Things You Need to Know
     
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