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They need to know if you have any of these conditions: -high cholesterol -liver disease -osteoporosis (weak bones) -an unusual or allergic reaction to letrozole, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding Take this medicine by mouth with a glass of water. Do not become pregnant while taking this medicine or for 3 weeks after stopping it. Do not take this medicine with any of the following medications: -estrogens, like hormone replacement therapy or birth control pills This medicine may also interact with the following medications: -dietary supplements such as androstenedione or DHEA -prasterone -tamoxifen This list may not describe all possible interactions. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. 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